[HTML][HTML] The technology and biology of single-cell RNA sequencing
The differences between individual cells can have profound functional consequences, in
both unicellular and multicellular organisms. Recently developed single-cell mRNA …
both unicellular and multicellular organisms. Recently developed single-cell mRNA …
Computational and analytical challenges in single-cell transcriptomics
The development of high-throughput RNA sequencing (RNA-seq) at the single-cell level has
already led to profound new discoveries in biology, ranging from the identification of novel …
already led to profound new discoveries in biology, ranging from the identification of novel …
[HTML][HTML] Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
Cells, the basic units of biological structure and function, vary broadly in type and state.
Single-cell genomics can characterize cell identity and function, but limitations of ease and …
Single-cell genomics can characterize cell identity and function, but limitations of ease and …
[HTML][HTML] Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
It has long been the dream of biologists to map gene expression at the single-cell level. With
such data one might track heterogeneous cell sub-populations, and infer regulatory …
such data one might track heterogeneous cell sub-populations, and infer regulatory …
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
The mammalian cerebral cortex supports cognitive functions such as sensorimotor
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …
A survey of human brain transcriptome diversity at the single cell level
The human brain is a tissue of vast complexity in terms of the cell types it comprises.
Conventional approaches to classifying cell types in the human brain at single cell …
Conventional approaches to classifying cell types in the human brain at single cell …
ZIFA: Dimensionality reduction for zero-inflated single-cell gene expression analysis
Single-cell RNA-seq data allows insight into normal cellular function and various disease
states through molecular characterization of gene expression on the single cell level …
states through molecular characterization of gene expression on the single cell level …
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells
Recent technical developments have enabled the transcriptomes of hundreds of cells to be
assayed in an unbiased manner, opening up the possibility that new subpopulations of cells …
assayed in an unbiased manner, opening up the possibility that new subpopulations of cells …
Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
AA Kolodziejczyk, JK Kim, JCH Tsang, T Ilicic… - Cell stem cell, 2015 - cell.com
Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …
Advances and applications of single-cell sequencing technologies
Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS …
studying rare cells and delineating complex populations. Over the past 5 years, SCS …