Evolving therapies for myocardial ischemia/reperfusion injury

B Ibáñez, G Heusch, M Ovize, F Van de Werf - Journal of the American …, 2015 - jacc.org
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

Coronary microvascular dysfunction: mechanisms and functional assessment

PG Camici, G d'Amati, O Rimoldi - Nature Reviews Cardiology, 2015 - nature.com
Obstructive disease of the epicardial coronary arteries was recognized as the cause of
angina pectoris> 2 centuries ago, and sudden thrombotic occlusion of an epicardial …

Effects of liraglutide on left ventricular function in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

WR Chen, SY Hu, Y Dai Chen, Y Zhang, G Qian… - American heart …, 2015 - Elsevier
Background Several studies have shown that exenatide protects against ischemia-
reperfusion injury and improves cardiac function in patients with acute ST-segment elevation …

Imaging of myocardial inflammation with somatostatin receptor based PET/CT—a comparison to cardiac MRI

C Lapa, T Reiter, X Li, RA Werner, S Samnick… - International journal of …, 2015 - Elsevier
Background Acute myocarditis as well as post-ischemic myocardial inflammation are
generally associated with a profound activation of the immune system. Current established …

MicroRNA-141 regulates the expression level of ICAM-1 on endothelium to decrease myocardial ischemia-reperfusion injury

RR Liu, J Li, JY Gong, F Kuang, JY Liu… - American Journal …, 2015 - journals.physiology.org
A growing number of studies have suggested microRNAs (miRNAs) are involved in the
modulation of myocardial ischemia-reperfusion (MI/R) injury; however, the role of …

Late gadolinium enhancement imaging in assessment of myocardial viability: techniques and clinical applications

LJ Juan, AM Crean, BJ Wintersperger - Radiologic Clinics, 2015 - radiologic.theclinics.com
Within just over a decade late gadolinium enhancement (LGE) imaging has become a
mainstay of cardiac magnetic resonance (MR) imaging supported by extensive study data …

Serial assessment of the index of microcirculatory resistance during primary percutaneous coronary intervention comparing manual aspiration catheter thrombectomy …

SP Hoole, C Jaworski, AJ Brown, LM McCormick… - Open …, 2015 - openheart.bmj.com
Objective Utilising a novel study design, we evaluated serial measurements of the index of
microcirculatory resistance (IMR) in patients undergoing primary percutaneous coronary …

Cardiac microvascular barrier function mediates the protection of Tongxinluo against myocardial ischemia/reperfusion injury

K Qi, L Li, X Li, J Zhao, Y Wang, S You, F Hu, H Zhang… - PloS one, 2015 - journals.plos.org
Objective Tongxinluo (TXL) has been shown to decrease myocardial necrosis after
ischemia/reperfusion (I/R) by simulating ischemia preconditioning (IPC). However, the core …

The impact of initial and residual thrombus burden on the no-reflow phenomenon in patients with ST-segment elevation myocardial infarction

SG Ahn, HH Choi, JH Lee, JW Lee, YJ Youn… - Coronary artery …, 2015 - journals.lww.com
Background Limited data are available on the clinical significance of residual thrombi after
thrombectomy and prestenting reduced epicardial coronary flow in ST-segment elevation …

Cardiovascular magnetic resonance for the assessment of coronary artery disease

A Gotschy, M Niemann, S Kozerke, TF Lüscher… - International journal of …, 2015 - Elsevier
Over the past decade, cardiovascular magnetic resonance (CMR) has become an
established non-invasive imaging modality in cardiology. It provides clinicians and …