Chronic lung infections are associated with increased morbidity and mortality for individuals
with underlying respiratory conditions such as cystic fibrosis (CF) and chronic obstructive …

Little is known about how within-host evolution compares between genotypically different
strains of the same pathogenic species. We sequenced the whole genomes of 474 …

Pseudomonas aeruginosa is the most common pathogen that colonizes the lungs of patients
with cystic fibrosis. Isolates from sputum are typically all derived from the same strain of …

Defining the essential genome of bacterial pathogens is central to developing an
understanding of the biological processes controlling disease. This has proven elusive for …

Changes in the airway microbiome may be important in the pathophysiology of chronic lung
disease in patients with cystic fibrosis. However, little is known about the microbiome in early …

Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …

Advances in high-throughput DNA sequencing allow for a comprehensive analysis of
bacterial genes that contribute to virulence in a specific infectious setting. Such information …

Cystic fibrosis lung disease is characterized by chronic airway infections with the
opportunistic pathogen Pseudomonas aeruginosa and severe neutrophilic pulmonary …

Rationale: Anaerobic bacteria are present in large numbers in the airways of people with
cystic fibrosis (PWCF). In the gut, anaerobes produce short-chain fatty acids (SCFAs) that …

Aspergillus fumigatus (Af) and Pseudomonas aeruginosa (Pa) are leading fungal and
bacterial pathogens, respectively, in many clinical situations. Relevant to this, their interface …