The estrogen-related receptors (ERRs) comprise a small group of orphan nuclear receptor
transcription factors. The ERRα and ERRγ isoforms play a central role in the regulation of …

The identification of the estrogen-related receptors (ERRs) as the first orphan nuclear
receptors ignited a new era in molecular endocrinology, which led to the discovery of new …

Objective The peptide hormone adropin regulates fuel selection preferences in skeletal
muscle under fed and fasted conditions. Here, we investigated whether adropin treatment …

Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction
contributes to numerous diseases, including heart failure. Here, we have shown that the …

PGC-1α is a transcriptional coactivator expressed in brown adipose tissue, liver, pancreas,
kidney, skeletal and cardiac muscles, and the brain. This review presents data illustrating …

Sustained Akt activation induces cardiac hypertrophy (LVH), which may lead to heart failure.
This study tested the hypothesis that Akt activation contributes to mitochondrial dysfunction …

We previously reported that Astragaloside IV (ASIV), a major active constituent of Astragalus
membranaceus (Fisch) Bge protects against cardiac hypertrophy in rats induced by …

The metabolic myocardium is an omnivore and utilizes various carbon substrates to meet its
energetic demand. While the adult heart preferentially consumes fatty acids (FAs) over …

Recent studies have reported multiple cases of molecular adaptation in cetaceans related to
their aquatic abilities. However, none of these has included the hippopotamus, precluding …

The NF-κB is found in almost all animal cell types and is involved in a myriad of cellular
responses. Aberrant expression of NF-κB has been linked to cancer, inflammatory diseases …