Platelets primarily mediate hemostasis and thrombosis, whereas leukocytes are responsible
for immune responses. Since platelets interact with leukocytes at the site of vascular injury …

Leukocytes recruitment to thrombi supports an intimate cellular interaction leading to the
enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular …

The role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in
overweight and obese patients with and without metabolic syndrome is still a matter of …

Microparticles (MP) are small (100–1000 nm) membrane vesicles shed by cells as a
response to activation, stress or apoptosis. Platelet-derived MP (PMP) has been shown to …

Thrombin is a central regulator of leukocyte recruitment and inflammation at sites of vascular
injury, a function thought to involve primarily endothelial PAR cleavage. Here we …

MVs, which can be subgrouped into exosomes, SVs, and OMVs, are secreted by eukaryotic
and prokaryotic cells. Many previously inexplicable phenomena can be explained by the …

The importance of factor Xa generation in thrombus formation has not been studied
extensively so far. Here, we used mice deficient in either factor VIII or factor IX to determine …

Inflammation has a pivotal role in cardiovascular disease because it contributes to the
progression of atherosclerosis, a chronic inflammatory disease of the vessel wall …

The hemostatic response requires the tightly regulated interaction of the coagulation system,
platelets, other blood cells and components of the vessel wall at a site of vascular injury. The …

Background While the incidence of thromboembolism in anti-neutrophil cytoplasmic
antibodies-associated vasculitis (AAV) is high, the coagulation and fibrinolysis profile in AAV …