Recent advances in organocatalytic cascade reactions toward the formation of quaternary stereocenters

F Vetica, RM de Figueiredo, M Orsini, D Tofani… - …, 2015 - thieme-connect.com
This review provides the authors' selection of recent publications that highlight the
increasing efforts to develop valuable organocatalytic domino/tandem/cascade reactions as …

Asymmetric Brønsted acid catalyzed synthesis of triarylmethanes—construction of communesin and spiroindoline scaffolds

HH Liao, A Chatupheeraphat, CC Hsiao… - Angewandte Chemie …, 2015 - Wiley Online Library
Aza‐ortho‐quinone methides allow the straightforward asymmetric synthesis of natural‐
product‐inspired indole scaffolds possessing a quaternary stereocenter. Our approach …

Progress toward the development of noscapine and derivatives as anticancer agents

A DeBono, B Capuano… - Journal of medicinal …, 2015 - ACS Publications
Many nitrogen-moiety containing alkaloids derived from plant origins are bioactive and play
a significant role in human health and emerging medicine. Noscapine, a …

Biology‐Oriented Synthesis of a Withanolide‐Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling

J Švenda, M Sheremet, L Kremer, L Maier… - Angewandte …, 2015 - Wiley Online Library
Biology‐oriented synthesis employs the structural information encoded in complex natural
products to guide the synthesis of compound collections enriched in bioactivity. The trans …

De novo branching cascades for structural and functional diversity in small molecules

M Garcia-Castro, L Kremer, CD Reinkemeier… - Nature …, 2015 - nature.com
The limited structural diversity that a compound library represents severely restrains the
discovery of bioactive small molecules for medicinal chemistry and chemical biology …

Highly Stereoselective Synthesis of Natural‐Product‐Like Hybrids by an Organocatalytic/Multicomponent Reaction Sequence

R Echemendía, AF de La Torre… - Angewandte Chemie …, 2015 - Wiley Online Library
In an endeavor to provide an efficient route to natural product hybrids, described herein is an
efficient, highly stereoselective, one‐pot process comprising an organocatalytic conjugate …

Highly Enantioselective Intramolecular 1, 3‐Dipolar Cycloaddition: A Route to Piperidino‐Pyrrolizidines

SR Vidadala, C Golz, C Strohmann… - Angewandte …, 2015 - Wiley Online Library
Abstract Enantioselective catalytic intermolecular 1, 3‐dipolar cycloadditions are powerful
methods for the synthesis of heterocycles. In contrast, intramolecular enantioselective 1, 3 …

Total synthesis of steroids and heterosteroids from BISTRO

M Ibrahim-Ouali - Steroids, 2015 - Elsevier
Total synthesis of steroids and heterosteroids from BISTRO - ScienceDirect Skip to main
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Asymmetrische Brønsted‐Säure‐katalysierte Synthese von Triarylmethanen–Aufbau von Communesin‐und Spiroindolin‐Gerüsten

HH Liao, A Chatupheeraphat, CC Hsiao… - Angewandte …, 2015 - Wiley Online Library
Aza‐ortho‐Chinonmethide ermöglichen eine effiziente asymmetrische Synthese Naturstoff‐
inspirierter Indolgerüste mit quartärem Stereozentrum. Mit diesem Ansatz konnten diverse …

A general catalytic reaction sequence to access alkaloid-inspired indole polycycles

A Danda, K Kumar, H Waldmann - Chemical Communications, 2015 - pubs.rsc.org
A catalytic two-step reaction sequence was developed to access a range of complex
heterocyclic frameworks based on biorelevant indole/oxindole scaffolds. The reaction …