Treatment-resistant depression: are animal models of depression fit for purpose?

P Willner, C Belzung - Psychopharmacology, 2015 - Springer
Background Resistance to antidepressant drug treatment remains a major health problem.
Animal models of depression are efficient in detecting effective treatments but have done …

Midbrain raphe 5-HT1A receptor activation alters the effects of ghrelin on appetite and performance in the elevated plus maze

SER Wauson, K Sarkodie… - Journal of …, 2015 - journals.sagepub.com
Prior research suggests that midbrain serotonergic signaling and hypothalamic ghrelinergic
signaling both play critical roles in appetitive and emotional behaviors. In the present study …

5-HT1B autoreceptors differentially modulate the expression of conditioned fear in a circuit-specific manner

Y Liu, MA Kelly, TJ Sexton, JF Neumaier - Neuroscience, 2015 - Elsevier
Located in the nerve terminals of serotonergic neurons, 5-HT 1B autoreceptors are poised to
modulate synaptic 5-HT levels with precise temporal and spatial control, and play an …

Pathogénicité du stress chronique chez l'adulte dans un modèle murin: impact à long terme et rôle de la somatostatine

T Prévot - 2015 - theses.hal.science
Le stress a une fonction adaptative mais son influence délétère sur la santé physique,
cognitive et mentale lorsqu'il se présente de façon excessive et/ou chronique est …