Autoimmune reactions reflect an imbalance between effector and regulatory immune
responses, typically develop through stages of initiation and propagation, and often show …

Inflammation is believed to play a central role in many of the chronic diseases that
characterize modern society. In the past decade, our understanding of how dietary fats affect …

Diet-induced obesity is associated to an imbalance in the normal gut microbiota
composition. Resveratrol and quercetin, widely known for their health beneficial properties …

Complications arising from dengue virus infection include potentially fatal vascular leak, and
severe disease has been linked with excessive immune cell activation. An understanding of …

Macrophages play a key role in immunity. In this review, we consider the traditional notion of
macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for …

Background & Aims The mechanisms of hypoxia-induced tumor growth remain unclear.
Hypoxia induces intracellular translocation and release of a variety of damage associated …

Induction of neuroimmune genes by binge drinking increases neuronal excitability and
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …

The key problem in human infectious diseases was posed at the turn of the 20th century:
their pathogenesis. For almost any given virus, bacterium, fungus, or parasite, life …

Traumatic injury to the central nervous system (CNS) or the peripheral nervous system
(PNS) triggers a cascade of events which culminate in a robust inflammatory reaction. The …

Parkinson's disease (PD) is an age-related movement disorder characterized by a
progressive degeneration of dopaminergic neurons in the midbrain. Although the presence …