Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia
DQ Tran, KT Erika, MH Kim, DD Belsham - Molecular and cellular …, 2016 - Elsevier
Diet-induced obesity can lead to detrimental chronic disorders. The severity of this global
epidemic has encouraged ongoing research to characterize the mechanisms underlying …
epidemic has encouraged ongoing research to characterize the mechanisms underlying …
Palmitate-induced endoplasmic reticulum stress and subsequent C/EBPα homologous protein activation attenuates leptin and Insulin-like growth factor 1 expression …
G Marwarha, K Claycombe, J Schommer, D Collins… - Cellular signalling, 2016 - Elsevier
The peptide hormones Insulin-like growth factor-1 (IGF1) and leptin mediate a myriad of
biological effects-both in the peripheral and central nervous systems. The transcription of …
biological effects-both in the peripheral and central nervous systems. The transcription of …
Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression
JG Vazquez-Jimenez, J Chavez-Reyes… - Cellular signalling, 2016 - Elsevier
Palmitic acid is a negative regulator of insulin activity. At the molecular level, palmitic acid
reduces insulin stimulated Akt Ser 473 phosphorylation. Interestingly, we have found that …
reduces insulin stimulated Akt Ser 473 phosphorylation. Interestingly, we have found that …
[HTML][HTML] Beneficial effects of metformin and/or salicylate on palmitate-or TNFα-induced neuroinflammatory marker and neuropeptide gene regulation in immortalized …
W Ye, EH Ramos, BC Wong, DD Belsham - PLoS One, 2016 - journals.plos.org
Neuropeptide Y (NPY)/Agouti-related peptide (AgRP)-expressing neurons in the
hypothalamus induce feeding and decrease energy expenditure. With consumption of a diet …
hypothalamus induce feeding and decrease energy expenditure. With consumption of a diet …
Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress
RG Snodgrass, S Huang, D Namgaladze… - The Journal of nutritional …, 2016 - Elsevier
Abstract Palmitic acid (C16: 0) and TLR2 ligand induce, but docosahexaenoic acid (DHA)
inhibits monocyte activation. C16: 0 and TLR2 or TLR4 ligand induce certain ER stress …
inhibits monocyte activation. C16: 0 and TLR2 or TLR4 ligand induce certain ER stress …
Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism
HJ Kwak, HE Choi, J Jang, SK Park, YA Bae… - Cellular signalling, 2016 - Elsevier
Bortezomib is an anti-cancer agent that induces ER stress by inhibiting proteasomal
degradation. However, the effects of bortezomib appear to be dependent on its …
degradation. However, the effects of bortezomib appear to be dependent on its …
[HTML][HTML] GIT2 acts as a systems-level coordinator of neurometabolic activity and pathophysiological aging
B Martin, W Chadwick, J Janssens… - Frontiers in …, 2016 - frontiersin.org
Aging represents one of the most complicated and highly integrated somatic processes.
Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal …
Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal …
Identification of 1, 2, 3-triazole derivatives that protect pancreatic β cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of …
The C/EBP-homologous protein (CHOP) acts as a mediator of endoplasmic reticulum (ER)
stress-induced pancreatic insulin-producing β cell death, a key element in the pathogenesis …
stress-induced pancreatic insulin-producing β cell death, a key element in the pathogenesis …
Fatty acids and hypothalamic dysfunction in obesity
Obesity is a significant problem for public health and the reasons for the increasing
prevalence of obesity are multifaceted, involving social and environmental factors with …
prevalence of obesity are multifaceted, involving social and environmental factors with …