Despite over 50 years of inhaled beta-agonists and corticosteroids as the default
management or rescue drugs for asthma, recent research suggests that new therapeutic …

Paediatric heart surgery is associated with increased inflammation and the production of
reactive oxygen species. Use of the extracorporeal cardiopulmonary bypass during …

Background The underlying molecular mechanisms leading to asthma remain largely
unclear. MicroRNAs (miRNAs) are short noncoding RNAs exert powerful effects on …

Despite the well-documented therapeutic effects of histone deacetylase inhibitor (HDACi) on
various diseases, including arthritis and asthma, the therapeutic effect of HDACi on allergic …

Background Recent studies have used cluster analysis to identify phenotypic clusters of
asthma with differences in clinical traits, as well as differences in response to therapy with …

The mechanisms contributing to persistent eosinophil activation and poor eosinopenic
response to glucocorticoids in severe asthma are poorly defined. We examined the effect of …

The mainstay of asthma therapy, glucocorticoids (GCs) exert their therapeutic effects through
the inhibition of inflammatory signaling and induction of eosinophil apoptosis. However …

Inflammation is a complex biological response to detrimental stimuli and can be a double‐
edged sword. Inflammation plays a protective role in removing pathogenic factors, but …

Background Although ethnicity may influence response to treatment of patients with asthma,
this approach is controversial. The objective of this study was to determine if ethnicity …

Abstract Heat shock protein 90 (HSP90) is an important glucocorticoid receptor (GR)
chaperone protein, and is supposed to be the key factor in regulating glucocorticoids (GCs) …