Identification of protein–protein interactions (PPIs) is at the center of molecular biology
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …

Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

The prediction of the quaternary structure of biomolecular macromolecules is of paramount
importance for fundamental understanding of cellular processes and drug design. In the era …

Abstract Structure determination of linear peptides of 5–50 amino acids in aqueous solution
and interacting with proteins is a key aspect in structural biology. PEP-FOLD3 is a novel …

Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that
catalyze oxidative cleavage of glycosidic bonds using molecular oxygen and an external …

Abstract F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this
enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and …

Uncontrolled self-association is a major challenge in the exploitation of proteins as
therapeutics. Here we describe the development of a structural proteomics approach to …

We present the results for CAPRI Round 30, the first joint CASP‐CAPRI experiment, which
brought together experts from the protein structure prediction and protein–protein docking …

Background Recent large-scale studies revealed cell-type specific proteomes. However,
protein complexes, the basic functional modules of a cell, have been so far mostly …

Aptamers, the chemical-antibody substitute to conventional antibodies, are primarily
discovered through SELEX technology involving multi-round selections and enrichment …