Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Base excision repair (BER) is one of several DNA repair pathways found in all three
domains of life. BER counters the mutagenic and cytotoxic effects of damage that occurs …

Alcohol consumption during pregnancy and its damaging consequences on the developing
infant brain are significant public health, social, and economic issues. The major distinctive …

Cervical cancer is the second most common cancer among women worldwide. About
528,000 women are diagnosed with cervical cancer contributing to around 266,000 deaths …

Psychiatric disease is believed to result from a combination of genetic vulnerability and
environmental influence. At the crux are epigenetic modifications, which mediate the …

Myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells composed
of progenitors and precursors to myeloid cells, are deemed to participate in the development …

DNA methylation and DNA methyltransferases (MTases)–the enzymes that introduce the
methylation mark into the DNA–have been studied for almost 70 years. In this chapter, we …

The directed differentiation of human cardiomyocytes (CMs) from pluripotent cells provides
an invaluable model for understanding mechanisms of cell fate determination and offers …

Levels of γ-aminobutyric acid (GABA) and glutamic acid decarboxylase 1 (GAD1), the
enzyme that synthesizes GABA, are significantly increased in neoplastic tissues. However …

The molecular basis of cellular memory is a fascinating topic that progressed with great
strides during the last few decades. In the case of cells of the immune system, cellular …