There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

The hippocampus and prefrontal cortex (PFC) have long been known to play a central role
in various behavioral and cognitive functions. More recently, electrophysiological and …

Several neuropsychiatric disorders are associated with cognitive and social dysfunction.
Postmortem studies of patients with schizophrenia have revealed specific changes in area …

Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for
schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control …

Abstract Background Individuals with 22q11. 2 Deletion Syndrome (22q11. 2 DS) are a
specific high-risk group for developing schizophrenia (SZ), schizoaffective disorder (SAD) …

Given the complexity and heterogeneity of the genomic architecture underlying
schizophrenia, molecular analyses of these patients with defined and large effect-size …

While the genetic basis of schizophrenia is increasingly well characterized, novel treatments
will require establishing mechanistic relationships between specific risk genes and core …

Highlights•Psychiatric disorders are heterogeneous disorders with complex genetic
origins.•Patient-specific hiPSCs can shed light on disease mechanisms.•Region-specific …

While the hippocampus has long been recognized as a brain structure specialized in
mapping 'space'in rodents, human studies and now recent data from rodents have shown …

Despite decades of research, the neural circuit abnormalities underlying schizophrenia
remain elusive. Although studies on schizophrenia patients have yielded important insights …