Non-membrane permeabilizing modes of action of antimicrobial peptides on bacteria

M Scocchi, M Mardirossian, G Runti… - Current topics in …, 2016 - ingentaconnect.com
Antimicrobial peptides (AMPs) are a large class of innate immunity effectors with a
remarkable capacity to inactivate microorganisms. Their ability to kill bacteria by …

[HTML][HTML] Antimicrobial activity of cationic antimicrobial peptides against gram-positives: current progress made in understanding the mode of action and the response …

S Omardien, S Brul, SAJ Zaat - Frontiers in cell and developmental …, 2016 - frontiersin.org
Antimicrobial peptides (AMPs) have been proposed as a novel class of antimicrobials that
could aid the fight against antibiotic resistant bacteria. The mode of action of AMPs as acting …

Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II

SA Cochrane, B Findlay, A Bakhtiary… - Proceedings of the …, 2016 - National Acad Sciences
Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity
against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by …

Lipid-based liquid crystals as carriers for antimicrobial peptides: phase behavior and antimicrobial effect

L Boge, H Bysell, L Ringstad, D Wennman, A Umerska… - Langmuir, 2016 - ACS Publications
The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for
novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an …

[HTML][HTML] An intimate link between antimicrobial peptide sequence diversity and binding to essential components of bacterial membranes

P Schmitt, RD Rosa, D Destoumieux-Garzón - Biochimica et biophysica …, 2016 - Elsevier
Antimicrobial peptides and proteins (AMPs) are widespread in the living kingdom. They are
key effectors of defense reactions and mediators of competitions between organisms. They …

The proteome targets of intracellular targeting antimicrobial peptides

P Shah, FSH Hsiao, YH Ho, CS Chen - Proteomics, 2016 - Wiley Online Library
Antimicrobial peptides have been considered well‐deserving candidates to fight the battle
against microorganisms due to their broad‐spectrum antimicrobial activities. Several studies …

A vancomycin derivative with a pyrophosphate‐binding group: a strategy to combat vancomycin‐resistant bacteria

V Yarlagadda, P Sarkar, S Samaddar… - Angewandte Chemie …, 2016 - Wiley Online Library
Vancomycin, the drug of last resort for Gram‐positive bacterial infections, has also been
rendered ineffective by the emergence of resistance in such bacteria. To combat the threat of …

Glycopeptide antibiotic to overcome the intrinsic resistance of Gram-negative bacteria

V Yarlagadda, GB Manjunath, P Sarkar… - ACS infectious …, 2016 - ACS Publications
The emergence of drug resistance along with a declining pipeline of clinically useful
antibiotics has made it vital to develop more effective antimicrobial therapeutics, particularly …

[HTML][HTML] Hit'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II

SF Oppedijk, NI Martin, E Breukink - Biochimica Et Biophysica Acta (BBA) …, 2016 - Elsevier
Understanding the mode of action of antibiotics is becoming more and more important in the
time that microorganisms start to develop resistance. One very well validated target of …

New antibiotics from Nature's chemical inventory

TA Wencewicz - Bioorganic & medicinal chemistry, 2016 - Elsevier
The doom and gloom of antibiotic resistance dominates public perception of this drug class.
Many believe the world has entered the post-antibiotic era. Classic and modern approaches …