In humans, the connection between sleep and mood has long been recognized, although
direct molecular evidence is lacking. We identified two rare variants in the circadian clock …

The identification of molecular networks at the system level in mammals is accelerated by
next-generation mammalian genetics without crossing, which requires both the efficient …

Absolute values of protein expression levels in cells are crucial information for
understanding cellular biological systems. Precise quantification of proteins can be …

Memory performance varies over a 24‐h day/night cycle. While the detailed underlying
mechanisms are yet unknown, recent evidence suggests that in the mouse hippocampus …

An extensive literature links circadian irregularities and/or sleep abnormalities to mood
disorders. Despite the strong genetic component underlying many mood disorders …

Dysfunctional clock signaling is observed in a variety of pathological conditions. Many
members of the clock gene family are upregulated in tumor cells. Here, we explored the …

Fu X, Li H, Yang K, Chen D, Tang H. Onco Targets Ther. 2016; 9: 2237–2245. The Editor
and Publisher of OncoTargets and Therapy are retracting the published article. Concerns …

It is claimed that a correlation exists between disturbance of circadian rhythms by factors
such as alteration of normal light–dark cycle and the development of addiction. However, the …

Abnormal expression of the clock gene PER1 is highly correlated with carcinogenesis and
the development of malignant tumors. Here, we designed short hairpin RNAs (shRNAs) to …

The various clock genes in normal cells, through their interaction, establish a number of
positive and negative feedback loops that compose a network structure. These genes play …