Antifungal agents: spectrum of activity, pharmacology, and clinical indications

JE Nett, DR Andes - Infectious Disease Clinics, 2016 - id.theclinics.com
Continued advancement of medical science offers life-saving treatment options for a variety
of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common …

Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America

TF Patterson, GR Thompson III… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Caspofungin: pharmacodynamics, pharmacokinetics, clinical uses and treatment outcomes

JC Song, DA Stevens - Critical reviews in microbiology, 2016 - Taylor & Francis
Over the past decade, echinocandins have emerged as first-line antifungal agents for many
Candida infections. The echinocandins have a unique mechanism of action, inhibiting the …

[HTML][HTML] JAID/JSC guidelines for the treatment of respiratory infectious diseases: the Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy …

K Mikasa, N Aoki, Y Aoki, S Abe, S Iwata… - Journal of Infection and …, 2016 - Elsevier
Concerning respiratory infectious diseases, in Japan, the Japanese Respiratory Society
published guidelines for the management of community-acquired pneumonia, hospital …

Recent developments in the management of invasive fungal infections in patients with oncohematological diseases

M Ruhnke, S Schwartz - Therapeutic advances in …, 2016 - journals.sagepub.com
Patients with hematological cancer have a high risk of invasive fungal diseases (IFDs).
These infections are mostly life threatening and an early diagnosis and initiation of …

Adoptive transfer of Aspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: Progress and challenges

A Papadopoulou, P Kaloyannidis, E Yannaki… - Critical Reviews in …, 2016 - Elsevier
Although newer antifungal drugs have substantially altered the natural history of invasive
aspergillosis, the disease still accounts for significant morbidity and mortality in …

Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections

KM Job, J Olson, C Stockmann… - Expert review of anti …, 2016 - Taylor & Francis
Introduction: Voriconazole is a broad-spectrum antifungal agent commonly used to treat
invasive fungal infections (IFI), including aspergillosis, candidiasis, Scedosporium infection …

Delay of antifungal therapy influences the outcome of invasive aspergillosis in experimental models of infection

F Barchiesi, A Santinelli, T Biscotti… - Journal of …, 2016 - academic.oup.com
Objectives The aim of the present study was to evaluate the effects of delayed antifungal
therapy on the outcome of invasive aspergillosis due to Aspergillus fumigatus in …

In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis

A Martin-Vicente, J Capilla, J Guarro - Antimicrobial Agents and …, 2016 - Am Soc Microbiol
Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high
mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to …

[HTML][HTML] Treatment of primary pulmonary aspergillosis: an assessment of the evidence

ER Stewart, GR Thompson III - Journal of Fungi, 2016 - mdpi.com
Aspergillus spp. are a group of filamentous molds that were first described due to a
perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when …