Pleiotropic and retinoprotective functions of PACAP

S Shioda, F Takenoya, N Wada, T Hirabayashi… - Anatomical science …, 2016 - Springer
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27-or 38-amino acid
neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin …

PACAP and neural development

J Watanabe, T Seki, S Shioda - Pituitary Adenylate Cyclase Activating …, 2016 - Springer
Brain development is a complex process, controlled in part by locally secreted factors that
regulate proliferation, differentiation, migration, survival, and maturation. Pituitary adenylate …

GPCRs direct germline development and somatic gonad function in planarians

A Saberi, A Jamal, I Beets, L Schoofs… - PLoS biology, 2016 - journals.plos.org
Planarians display remarkable plasticity in maintenance of their germline, with the ability to
develop or dismantle reproductive tissues in response to systemic and environmental cues …

Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular …

A Lamine, M Létourneau, ND Doan, J Maucotel… - …, 2016 - Elsevier
Parkinson's disease (PD) is characterized by a steady loss of dopamine neurons through
apoptotic, inflammatory and oxidative stress processes. In that line of view, the pituitary …

PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression

G Maugeri, A Grazia D'Amico, R Reitano… - Frontiers in …, 2016 - frontiersin.org
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal
peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform …

Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse

SZ Jiang, LE Eiden - Stress, 2016 - Taylor & Francis
We measured serum CORT elevation in wild-type and PACAP-deficient C57BL/6N male
mice after acute (1 h) or prolonged (2–3 h) daily restraint stress for 7 d. The PACAP …

[HTML][HTML] Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease

A Lamine-Ajili, AM Fahmy, M Létourneau… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder that leads to destruction of the
midbrain dopaminergic (DA) neurons. This phenomenon is related to apoptosis and its …

Seasonal variation in group size is related to seasonal variation in neuropeptide receptor density

LC Wilson, JL Goodson, MA Kingsbury - Brain, Behavior and Evolution, 2016 - karger.com
In many species, seasonal variation in grouping behavior is widespread, with shifts towards
territoriality in the breeding season and grouping in the winter. Compared to the hormonal …

Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates the hypothalamo-pituitary-thyroid (HPT) axis via type 2 deiodinase in male mice

P Egri, C Fekete, Á Dénes, D Reglődi… - …, 2016 - academic.oup.com
The hypothalamic activation of thyroid hormones by type 2 deiodinase (D2), catalyzing the
conversion of thyroxine to T3, is critical for the proper function of the hypothalamo-pituitary …

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

G Aquino-Miranda, J Escamilla-Sánchez… - …, 2016 - Elsevier
We studied the effect of activating histamine H 3 receptors (H 3 Rs) on rat nucleus
accumbens (rNAcc) dopaminergic transmission by analyzing [3 H]-dopamine uptake by …