Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …

Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm
for a ubiquitously expressed transcription factor and is involved in regulating the expression …

Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …

The genome is subject to a diverse array of epigenetic modifications from DNA methylation
to histone posttranslational changes. Many of these marks are somatically stable through …

DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.
Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often …

Empirical models of sequence evolution have spurred progress in the field of evolutionary
genetics for decades. We are now realizing the importance and complexity of the eukaryotic …

FABPs (fatty-acid-binding proteins) are a family of low-molecular-mass intracellular lipid-
binding proteins consisting of ten isoforms. FABPs are involved in binding and storing …

Core promoters are minimal regions sufficient to direct accurate initiation of transcription and
are crucial for regulation of gene expression. They are highly diverse in terms of associated …

Abstract Imprinting Control Regions (ICRs) need to maintain their parental allele-specific
DNA methylation during early embryogenesis despite genome-wide demethylation and …

Abstract Toll-like receptor 4 (TLR4) is important in promoting the immune response in
various cancers. Recently, TLR4 is highly expressed in a stage-dependent manner in gastric …