The impact of comorbidity on cancer and its treatment

D Sarfati, B Koczwara, C Jackson - CA: a cancer journal for …, 2016 - Wiley Online Library
Answer questions and earn CME/CNE Comorbidity is common among cancer patients and,
with an aging population, is becoming more so. Comorbidity potentially affects the …

[HTML][HTML] The “efficacy-effectiveness gap”: historical background and current conceptualization

C Nordon, H Karcher, RHH Groenwold, MZ Ankarfeldt… - Value in Health, 2016 - Elsevier
Background The concept of the “efficacy-effectiveness gap”(EEG) has started to challenge
confidence in decisions made for drugs when based on randomized controlled trials alone …

[HTML][HTML] Role of clinical trial participation in cancer research: barriers, evidence, and strategies

JM Unger, E Cook, E Tai, A Bleyer - American Society of Clinical …, 2016 - ncbi.nlm.nih.gov
Fewer than 1 in 20 adult cancer patients enroll in cancer clinical trials. But although barriers
to trial participation have been the subject of frequent study, the rate of trial participation has …

Enrollment trends and disparity among patients with lung cancer in national clinical trials, 1990 to 2012

HH Pang, X Wang, TE Stinchcombe… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Under-representation of elderly, women, and racial/ethnic minority patients with
cancer in clinical trials is of national concern. The goal of this study was to characterize …

[HTML][HTML] Inclusion of elderly patients in oncology clinical trials

O Le Saux, C Falandry, HK Gan, B You, G Freyer… - Annals of …, 2016 - Elsevier
Background Physicians need clinical trials assessing benefits and harms of treatments to
avoid under-treatment or over-treatment of elderly patients. The main objectives of this report …

Disparities in cancer treatment among patients infected with the human immunodeficiency virus

G Suneja, CC Lin, EP Simard, X Han, EA Engels… - Cancer, 2016 - Wiley Online Library
BACKGROUND Patients with cancer who are infected with the human immunodeficiency
virus (HIV) are less likely to receive cancer treatment compared with HIV‐uninfected …

Impact of geriatric assessment on the management of older adults with head and neck cancer: a pilot study

M Neve, MB Jameson, S Govender… - Journal of geriatric …, 2016 - Elsevier
Objective Assess the utility of the G8 screening tool and CGA for older adults with head and
neck cancer. Methods Patients 65 years or older with a primary malignancy of the head and …

Prostate cancer registries: current status and future directions

G Gandaglia, F Bray, MR Cooperberg, RJ Karnes… - European urology, 2016 - Elsevier
Context Disease-specific registries that enroll a considerable number of patients play a
major role in prostate cancer (PCa) research. Objective To evaluate available registries …

[HTML][HTML] Chemotherapy in elderly patients with gastric cancer

HS Kim, JH Kim, JW Kim, BC Kim - Journal of Cancer, 2016 - ncbi.nlm.nih.gov
Gastric cancer (GC) is one of the most frequent malignant diseases in the elderly. Systemic
chemotherapy showed an improvement of quality of life and survival benefit compared to …

Immune checkpoint inhibitors in older adults

R Elias, J Morales, Y Rehman, H Khurshid - Current Oncology Reports, 2016 - Springer
Cancer is primarily a disease of older adults. The treatment of advanced stage tumors
usually involves the use of systemic agents that may be associated with significant risk of …