In the past decades, studies of the Janus kinases (JAKs) and signal transducers and
activators of transcription (STATs) signaling have uncovered highly conserved programs …

Myeloproliferative neoplasms (MPN) are clonal stem cell diseases, first conceptualized in
1951 by William Dameshek, and historically included chronic myeloid leukemia (CML) …

Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular
responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene …

Transformation to secondary myelofibrosis (MF) occurs as part of the natural history of
polycythemia vera (PPV‐MF) and essential thrombocythemia (PET‐MF). Although primary …

Hematopoietic cell transplantation (HCT) is the only curative therapeutic modality for
myelofibrosis (MF) at present. The optimal timing of HCT is not known in the presence of …

Lung cancer, with its most prevalent form non-small-cell lung carcinoma (NSCLC), is one of
the leading causes of cancer-related deaths worldwide, and is commonly treated with …

The kidney, through the distinct processes of passive glomerular filtration and active tubular
secretion, plays an important role in the elimination of numerous endobiotics (eg, hormones …

New molecular genetics in the diagnosis and treatment of mye... : Current Opinion in
Hematology New molecular genetics in the diagnosis and treatment of myeloproliferative …

CALR mutations are identified in about 30% of JAK2/MPL-unmutated myeloproliferative
neoplasms (MPNs) including essential thrombocythemia (ET) and primary myelofibrosis …

STAT3 is an important signaling molecule that modulates a wide range of genes by relaying
extracellular signals from the plasma membrane to the nucleus in response to peptide …