Optogenetics is an emerging and powerful technique that allows the control of protein
activity with light. The possibility of inhibiting or stimulating protein activity with the spatial …

The establishment of left–right (LR) asymmetry in vertebrates is dependent on the sensory
and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt LR …

Collective cell migration is an essential process during embryonic development and
diseases such as cancer, and still much remains to be learned about how cell intrinsic and …

Background: Cell polarity is essential for directed migration of mesenchymal cells and
morphogenesis of epithelial tissues. Studies in cultured cells indicate that a condensed …

Genetic perturbation methods have played an important role in elucidating the
organizational principles of biological systems. Forward genetics involves the systematic …

In a departure from the detailed reviews of in vitro screening given in previous chapters, we
will focus on large scale in vivo screens. Our discussion of these 'phenotypic'screens will …