The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …

Non-coding RNAs represent a majority of the human transcriptome. However, less is known
about the functions and regulatory mechanisms of most non-coding species. Moreover, little …

It has recently been shown that the upregulation of a pseudogene specific to a protein-
coding gene could function as a sponge to bind multiple potential targeting microRNAs …

Abstract MiR-671-5p is encoded by a gene localized at 7q36. 1, a region amplified in human
glioblastoma multiforme (GBM), the most malignant brain cancer. To investigate whether …

Pancreatic cancer (PaCa) has the highest death rate and incidence is increasing. Poor
prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor …

Breast cancer, the most common cancer among women, is a heterogeneous and complex
disease, which detail of its precise progression mechanisms is less understood. So, an …

Constitutive activation of the Wnt/β-catenin pathway promotes malignant proliferation and it
is inversely correlated with the prognosis of patients with breast cancer. However, mutations …

Epidemiological findings support the concept of Developmental Origins of Health and
Disease, suggesting that early-life hormonal influences during a sensitive period of …

Solid tumors require angiogenesis to grow beyond 2 mm in size. In most cases, tumor cells
undergo angiogenic switch and secrete substances that are required for generation of new …

Purpose Retinal degenerative diseases (RDDs) affect millions of people and are the leading
cause of vision loss. Although treatment options for RDDs are limited, stem and progenitor …