Role of sirtuins in regulating pathophysiology of the heart
S Bindu, VB Pillai, MP Gupta - Trends in Endocrinology & Metabolism, 2016 - cell.com
Cardiovascular diseases (CVDs) are expanding at an alarming rate and people's propensity
to develop them increases with age. Growing evidence indicates that sirtuins play a pivotal …
to develop them increases with age. Growing evidence indicates that sirtuins play a pivotal …
[HTML][HTML] Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer
CH Wong, YJ Li, YC Chen - World journal of gastroenterology, 2016 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is a common pancreatic cancer and the fourth
leading cause of cancer death in the United States. Treating this life-threatening disease …
leading cause of cancer death in the United States. Treating this life-threatening disease …
SIRT1 and neural cell fate determination
Y Cai, L Xu, H Xu, X Fan - Molecular Neurobiology, 2016 - Springer
During the development of the central nervous system (CNS), neurons and glia are derived
from multipotent neural stem cells (NSCs) undergoing self-renewal. NSC commitment and …
from multipotent neural stem cells (NSCs) undergoing self-renewal. NSC commitment and …
[HTML][HTML] Sirtuin 1 promotes deacetylation of Oct4 and maintenance of naive pluripotency
The enhancer landscape is dramatically restructured as naive preimplantation epiblasts
transition to the post-implantation state of primed pluripotency. A key factor in this process is …
transition to the post-implantation state of primed pluripotency. A key factor in this process is …
SIRT1 in metabolic health and disease
M Boutant, C Cantó - Sirtuins, 2016 - Springer
When the activity of SIRT1 was unraveled as an NAD+-dependent deacetylase, the
possibility of coupling metabolic changes to transcriptional outputs was rapidly envisioned …
possibility of coupling metabolic changes to transcriptional outputs was rapidly envisioned …