The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-
characterized inbred strains of mice that can be used to analyze the genetic and …

Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …

Variance-component methods that estimate the aggregate contribution of large sets of
variants to the heritability of complex traits have yielded important insights into the genetic …

Genome-wide association studies (GWAS) have successfully identified thousands of
associations between common genetic variants and human disease phenotypes, but the …

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

Background: Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by …

Rationale: Obstructive sleep apnea is a common disorder associated with increased risk for
cardiovascular disease, diabetes, and premature mortality. Although there is strong clinical …

Implementing precision medicine for complex diseases such as chronic obstructive lung
disease (COPD) will require extensive use of biomarkers and an in-depth understanding of …