In the past decade important progress has been made in our understanding of the
epigenetic regulatory machinery. It has become clear that genetic aberrations in multiple …

Chromatin-based DNA damage response (DDR) pathways are fundamental for preventing
genome and epigenome instability, which are prevalent in cancer. Histone …

Purpose AZD1775 is a WEE1 kinase inhibitor targeting G2 checkpoint control, preferentially
sensitizing TP53-deficient tumor cells to DNA damage. This phase I study evaluated safety …

One recurring theme in drug development is to exploit synthetic lethal properties as means
to preferentially damage the DNA of cancer cells. We and others have previously developed …

Enteropathy-associated T-cell lymphoma (EATL), a rare and aggressive intestinal
malignancy of intraepithelial T lymphocytes, comprises two disease variants (EATL-I and …

Renal cell carcinomas with unclassified histology (uRCC) constitute a significant portion of
aggressive non-clear cell renal cell carcinomas that have no standard therapy. The …

Oncogene-evoked replication stress (RS) fuels genomic instability in diverse cancer types.
Here we report that BRCA1, traditionally regarded a tumour suppressor, plays an …

A dividing cell has to duplicate its DNA precisely once during the cell cycle to preserve
genome integrity avoiding the accumulation of genetic aberrations that promote diseases …

Chordoma is a rare primary bone neoplasm that is resistant to standard chemotherapies.
Despite aggressive surgical management, local recurrence and metastasis is not …

Arsenic is a human carcinogen and also increases the risk for non-cancer outcomes.
Arsenic-induced epigenetic dysregulation may contribute to arsenic toxicity. Although there …