HCN channels modulators: the need for selectivity
M Novella Romanelli, L Sartiani, A Masi… - Current Topics in …, 2016 - ingentaconnect.com
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular
correlate of the hyperpolarization-activated current (If/Ih), are membrane proteins which play …
correlate of the hyperpolarization-activated current (If/Ih), are membrane proteins which play …
[HTML][HTML] Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP−/− Mice
J Fan, PL Stemkowski, MA Gandini, SA Black… - Frontiers in cellular …, 2016 - frontiersin.org
Genetic ablation of cellular prion protein (PrPC) has been linked to increased neuronal
excitability and synaptic activity in the hippocampus. We have previously shown that …
excitability and synaptic activity in the hippocampus. We have previously shown that …
Method for identifying small molecule inhibitors of the protein-protein interaction between HCN1 and TRIP8b
Y Han, KA Lyman, M Clutter, GE Schiltz… - JoVE (Journal of …, 2016 - jove.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed
ubiquitously throughout the brain, where they function to regulate the excitability of neurons …
ubiquitously throughout the brain, where they function to regulate the excitability of neurons …