Aging is one of the most important risk factors for most chronic diseases. The worldwide
increase in life expectancy has been accompanied by an increase in the prevalence of age …

Life expectancy has grown dramatically in modern times. This increase, however, is not
accompanied by the same increase in healthspan. Efforts to extend healthspan through …

Animal life-history traits fall within a limited ecological space, a continuum referred to as a
“slow-fast” life-history axis. Differences of life-history traits are thought to result from trade …

Oxidative damage is predicted to be a mediator of trade-offs between current reproduction
and future reproduction or survival, but most studies fail to support such predictions. We …

Abstract d-Galactose (d-gal) is a reducing sugar that can be used to mimic the
characteristics of aging in rodents; however, the effects of d-gal administration by oral route …

The aim of the present study was to investigate the anti-aging effects of rhein lysinate (RHL),
and to explore its mechanism of action in a D‑galactose‑induced aging mouse model. Aging …

Background Dietary modification, through supplementation and elimination diets, has
become an area of interest to help slow skin aging, reduce symptom severity or prevent …

Oxidative damage has been proposed as a potential mechanism underlying a life history
tradeoff between survival and reproduction. However, evidence that reproduction is …

There is a growing interest in the physiological roles of reactive oxygen species (ROS) as
essential components of molecular mechanisms regulating key cellular processes, including …

In response to prolonged periods of fasting, animals have evolved metabolic adaptations
helping to mobilize body reserves and/or reduce metabolic rate to ensure a longer usage of …