In vitro tissue/organ models are useful platforms that can facilitate systematic, repetitive, and
quantitative investigations of drugs/chemicals. The primary objective when developing …

The functional maturation and preservation of hepatic cells derived from human induced
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …

Viral hepatitis is a major cause of morbidity and mortality, affecting hundreds of millions of
people worldwide. Hepatitis-causing viruses initiate disease by establishing both acute and …

Microfluidic organ-on-a-chip technology aims to replace animal toxicity testing, but thus far
has demonstrated few advantages over traditional methods. Mitochondrial dysfunction plays …

Three-dimensional (3D) tissue modeling is an emerging field of investigation for disease
mechanisms, drug testing, and therapeutic effects for human survival. Various methods have …

Traditional in vitro human liver cell culture models lose key hepatic functions such as
metabolic activity during short-term culture. Advanced three-dimensional (3D) liver coculture …

Drug‐induced liver injury (DILI) is a major cause of drug attrition. Testing drugs on human
liver models is essential to mitigate the risk of clinical DILI since animal studies do not …

During the last decades, the engineering of well‐defined 3D tissues has attracted great
attention because it provides in vivo mimicking environment and can be a building block for …

Development of predictive multi-organ models before implementing costly clinical trials is
central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite …

Hepatitis B virus (HBV) is not eradicated by current antiviral therapies due to persistence of
HBV covalently closed circular DNA (cccDNA) in host cells and thus development of novel …