The phosphatidylinositol‐3 kinase (PI3K)–AKT pathway is one of the most commonly
dysregulated pathways in all of cancer, with somatic mutations, copy number alterations …

In addition to each of the factors that govern the identification of a successful oncology drug
candidate, drug discovery aimed at treating neurological cancer must also consider the …

Cancer cells, stem cells and cancer stem cells have for a long time played a significant role
in the biomedical sciences. Though cancer therapy is more effective than it was a few years …

Epithelial-to-mesenchymal transition (EMT) is an essential physiologic process that
promotes cancer cell migration, invasion, and metastasis. Several lines of evidence from …

Background Treatment of breast cancer patients with distant metastases represents one of
the biggest challenges in today's gynecological oncology. Therefore, a better understanding …

Background Akt (PKB) is a serine threonine protein kinase downstream of the
phosphoinositide 3-kinase (PI3K) pathway. In mammals, Akt is ubiquitously expressed and …

CNS germinomas represent a unique germ cell tumor entity characterized by
undifferentiated tumor cells and a high response rate to current treatment protocols. Limited …

The regulatory subunit of PI3K, p85α (encoded by PIK3R1), binds, stabilizes and inhibits the
PI3K p110 catalytic subunit. Functional characterization of PIK3R1 mutations has identified …

Human immunodeficiency virus (HIV) is the causative agent of the deadly disease AIDS,
which is characterized by the progressive decline of CD4+ T-cells. HIV-1-encoded proteins …

Elucidating mechanisms of chemoresistance is critical to improve cancer therapy, especially
for the treatment of pancreatic ductal adenocarcinoma (PDAC). Genome-wide association …