The multiple roles played by RNA binding proteins in neurodegeneration have become
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …

Abstract Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in
adults. Classical ALS is characterized by the death of upper and lower motor neurons …

An intronic expansion of GGGGCC repeats within the C9 ORF 72 gene is the most common
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS‐FTD) …

FUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are often …

Disruptions to genes linked to RNA processing and homeostasis are implicated in the
pathogenesis of two pathologically related but clinically heterogeneous neurodegenerative …

Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per
100,000 people worldwide, encompasses at least five distinct pathological subtypes …

Widespread genetic modification of cells in the central nervous system (CNS) with a viral
vector has become possible and increasingly more efficient. We previously applied an AAV9 …

TAR DNA-binding protein of 43 kDa (TDP-43) has been identified as the major component
of ubiquitin-positive neuronal and glial inclusions in frontotemporal lobar degeneration and …

The RNA-binding protein TDP-43 forms intracellular inclusions in amyotrophic lateral
sclerosis (ALS). While TDP-43 mutations have been identified in ALS patients, how these …

Fused in Sarcoma (FUS) is a multifunctional RNA-/DNA-binding protein, which is involved in
the pathogenesis of the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) …