Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance
D Grimwade, A Ivey, BJP Huntly - Blood, The Journal of the …, 2016 - ashpublications.org
Recent major advances in understanding the molecular basis of acute myeloid leukemia
(AML) provide a double-edged sword. Although defining the topology and key features of …
(AML) provide a double-edged sword. Although defining the topology and key features of …
Acute myeloid leukaemia
A Khwaja, M Bjorkholm, RE Gale, RL Levine… - Nature reviews Disease …, 2016 - nature.com
Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …
Assessment of minimal residual disease in standard-risk AML
A Ivey, RK Hills, MA Simpson… - … England Journal of …, 2016 - Mass Medical Soc
Background Despite the molecular heterogeneity of standard-risk acute myeloid leukemia
(AML), treatment decisions are based on a limited number of molecular genetic markers and …
(AML), treatment decisions are based on a limited number of molecular genetic markers and …
Mutations in AML: prognostic and therapeutic implications
CD DiNardo, JE Cortes - Hematology 2014, the American …, 2016 - ashpublications.org
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized
by the proliferation and aberrant differentiation of immature clonal myeloid cells. The …
by the proliferation and aberrant differentiation of immature clonal myeloid cells. The …
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly
expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found …
expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found …
[HTML][HTML] Galectin 3 as a guardian of the tumor microenvironment
PP Ruvolo - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2016 - Elsevier
Galectin 3 is a member of a family of β-galactoside binding proteins and has emerged as an
important regulator of diverse functions critical in cancer biology including apoptosis …
important regulator of diverse functions critical in cancer biology including apoptosis …
Nucleophosmin: from structure and function to disease development
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of
pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability …
pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability …
Genetically distinct leukemic stem cells in human CD34− acute myeloid leukemia are arrested at a hemopoietic precursor-like stage
L Quek, GW Otto, C Garnett, L Lhermitte… - Journal of Experimental …, 2016 - rupress.org
Our understanding of the perturbation of normal cellular differentiation hierarchies to create
tumor-propagating stem cell populations is incomplete. In human acute myeloid leukemia …
tumor-propagating stem cell populations is incomplete. In human acute myeloid leukemia …
Acute myeloid leukemia--major progress over four decades and glimpses into the future.
H Kantarjian - American Journal of Hematology, 2016 - europepmc.org
Acute myeloid leukemia--major progress over four decades and glimpses into the future. -
Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About …
Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About …
Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies
The nuclear export receptor, Exportin 1 (XPO1), mediates transport of growth-regulatory
proteins, including tumor suppressors, and is overactive in many cancers, including chronic …
proteins, including tumor suppressors, and is overactive in many cancers, including chronic …