The recent approval of vaccines and gene therapy products for human use produced in the
Insect Cell-Baculovirus Expression Vector System (IC-BEVS) underlines the high potential …

Adenovirus vectors (AdV) constitute very powerful vehicles for gene transfer with
applications in vaccination, cancer treatment, and many monogenic and acquired diseases …

Canine adenovirus vector type 2 (CAV2) represents an alternative to human adenovirus
vectors for certain gene therapy applications, particularly neurodegenerative diseases …

The generation of human neural tissue-like 3D structures holds great promise for disease
modeling, drug discovery and regenerative medicine strategies. Promoting the …

The neuroprotective role of carbon monoxide (CO) has been studied in a cell-autonomous
mode. Herein, a new concept is disclosed–CO affects astrocyte–neuron communication in a …

Many mammalian cell lines used in the manufacturing of biopharmaceuticals exhibit high
glycolytic flux predominantly channeled to the production of lactate. The accumulation of …

Background The estimation of intracellular flux through traditional metabolic flux analysis
(MFA) using an overdetermined system of equations is a well established practice in …

The immature phenotype of human pluripotent stem cell derived cardiomyocytes (hPSC-CM)
is currently the main drawback limiting the potential of these cells for applications in cell …

The growing availability of genomic, transcriptomic, and metabolomic data has opened the
door to the synthesis of multiple levels of information in biological research. As a …

Three dimensional (3D) cultures of human pluripotent stem cell derived cardiomyocytes
(hPSC-CMs) are more predictable models of in vivo responses to be used for drug discovery …