Toward development of iMesenchymal stem cells for immunomodulatory therapy

SFH De Witte, M Franquesa, CC Baan… - Frontiers in …, 2016 - frontiersin.org
Mesenchymal stem cells (MSC) are under development as an immunomodulatory therapy.
The anticipated immunomodulatory effects of MSC are broad, from direct inhibition of …

Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions

M Di Trapani, G Bassi, M Midolo, A Gatti… - Scientific reports, 2016 - nature.com
Mesenchymal stromal cells (MSCs) are multipotent cells, immunomodulatory stem cells that
are currently used for regenerative medicine and treatment of a number of inflammatory …

Cryopreserved mesenchymal stromal cells are susceptible to T-cell mediated apoptosis which is partly rescued by IFNγ licensing

R Chinnadurai, IB Copland, MA Garcia… - Stem Cells, 2016 - academic.oup.com
We have previously demonstrated that cryopreservation and thawing lead to altered
Mesenchymal stromal cells (MSC) functionalities. Here, we further analyzed MSC's fitness …

Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively

B Huang, X Cheng, H Wang, W Huang… - Journal of translational …, 2016 - Springer
Background Orthotopic liver transplantation is the only effective treatment for liver failure but
limited with shortage of available donor organs. Recent studies show promising results of …

Adipose‐derived mesenchymal stem cells modulate the immune response in chronic experimental autoimmune encephalomyelitis model

SM Shalaby, NA Sabbah, T Saber… - IUBMB life, 2016 - Wiley Online Library
Multiple sclerosis (MS) is an autoimmune inflammatory neurodegenerative disease of the
central nervous system (CNS) that disrupts the myelin sheath, leading to dysfunction of the …

In vivo immunomodulatory effects of adipose-derived mesenchymal stem cells conditioned medium in experimental autoimmune encephalomyelitis

F Yousefi, M Ebtekar, S Soudi, M Soleimani… - Immunology letters, 2016 - Elsevier
Mesenchymal stem cells (MSCs) are well known to possess neuroprotective and
immunomodulatory effects, due to cell-to-cell interaction and their soluble factors. We …

Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE

AM Vega-Letter, M Kurte, C Fernández-O'Ryan… - Stem cell research & …, 2016 - Springer
Background Recently, it has been observed that mesenchymal stem cells (MSCs) can
modulate their immunoregulatory properties depending on the specific in-vitro activation of …

Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model

P Cruz-Martinez, S González-Granero… - Cell death & …, 2016 - nature.com
Current treatments for demyelinating diseases are generally only capable of ameliorating
the symptoms, with little to no effect in decreasing myelin loss nor promoting functional …

Enhanced neuroprotective effects of combination therapy with bone marrow-derived mesenchymal stem cells and Ginkgo biloba extract (EGb761) in a rat model of …

F Hao, A Li, H Yu, M Liu, Y Wang, J Liu… - …, 2016 - karger.com
Objectives: We investigated whether Ginkgo biloba extract (EGb761) can provide
neuroprotective effects and enhance the efficacy of bone marrow-derived mesenchymal …

Mesenchymal stem/stromal cell therapy: mechanism of action and host response

A Ryan, M Murphy, F Barry - The Biology and Therapeutic …, 2016 - Wiley Online Library
The use of mesenchymal stem or stromal cells (MSCs) transplantation for tissue repair has
received a great deal of attention in recent years, and these cells stand at the forefront of …