Pathophysiology of radiation-induced dysphagia in head and neck cancer

SN King, NE Dunlap, PA Tennant, T Pitts - Dysphagia, 2016 - Springer
Oncologic treatments, such as curative radiotherapy and chemoradiation, for head and neck
cancer can cause long-term swallowing impairments (dysphagia) that negatively impact …

IMRT for head and neck cancer: reducing xerostomia and dysphagia

XS Wang, A Eisbruch - Journal of radiation research, 2016 - academic.oup.com
Dysphagia and xerostomia are the main sequellae of chemoradiotherapy for head and neck
cancer, and the main factors in reducing long-term patient quality of life. IMRT uses …

DARS: a phase III randomised multicentre study of dysphagia-optimised intensity-modulated radiotherapy (Do-IMRT) versus standard intensity-modulated …

I Petkar, K Rooney, JWG Roe, JM Patterson… - BMC cancer, 2016 - Springer
Background Persistent dysphagia following primary chemoradiation (CRT) for head and
neck cancers can have a devastating impact on patients' quality of life. Single arm studies …

Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: dose–volume correlates of chronic radiation-associated dysphagia …

T Dale, K Hutcheson, ASR Mohamed, JS Lewin… - Radiotherapy and …, 2016 - Elsevier
Purpose/objective (s) We sought to identify swallowing muscle dose–response thresholds
associated with chronic radiation-associated dysphagia (RAD) after IMRT for oropharyngeal …

[HTML][HTML] Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: clinical validation according to the model-based approach

MEMC Christianen, A van der Schaaf… - Radiotherapy and …, 2016 - Elsevier
Purpose The aim of this study was to clinically validate a multivariable normal tissue
complication probability (NTCP) model for grade 2–4 swallowing dysfunction at 6 months …

Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose–volume analysis

R Mazzola, F Ricchetti, S Fersino, A Fiorentino… - Head & …, 2016 - Wiley Online Library
Background The purpose of this study was to assess predictors of mucositis in
oropharyngeal and oral cavity cancer after definitive or adjuvant volumetric modulated arc …

Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2–4 dysphagia and tube feeding dependence in head and …

RGJ Kierkels, K Wopken, R Visser, EW Korevaar… - Radiotherapy and …, 2016 - Elsevier
Background and purpose Radiotherapy of the head and neck is challenged by the relatively
large number of organs-at-risk close to the tumor. Biologically-oriented objective functions …

Impact of feeding tube choice on severe late dysphagia after definitive chemoradiotherapy for human papillomavirus–negative head and neck cancer

MC Ward, P Bhateja, T Nwizu, J Kmiecik… - Head & …, 2016 - Wiley Online Library
Background Severe late dysphagia is common after chemoradiotherapy for cancers of the
larynx and oropharynx. Options for reduction of severe late dysphagia are limited for human …

[HTML][HTML] How does radiotherapy impact swallowing function in nasopharynx and oropharynx cancer? Short-term results of a prospective study

S Ursino, V Seccia, P Cocuzza, P Ferrazza… - Acta …, 2016 - ncbi.nlm.nih.gov
The objective of this study is to report the initial results of a prospective trial assessing
instrumental deglutition function in nasopharynx and oropharynx cancers after radio or …

Radiation dose to dysphagia aspiration-related structures and its effect on swallowing: comparison of three-dimensional conformal radiotherapy and intensity …

CG Prameela, R Ravind, PSR Mon… - Journal of Cancer …, 2016 - journals.lww.com
Aims: The aim of this study was to compare radiation dose to dysphagia aspiration related
structures (DARS) in intensity modulated radiation therapy (IMRT) and three-dimensional …