[PDF][PDF] The microbiome, timing, and barrier function in the context of allergic disease

DR Wesemann, CR Nagler - Immunity, 2016 - cell.com
Allergic disease affects millions. Despite many advances in our understanding of the
immune system in the past century, the physiologic underpinning for the existence of allergy …

Age‐associated B cells: key mediators of both protective and autoreactive humoral responses

MS Naradikian, Y Hao, MP Cancro - Immunological reviews, 2016 - Wiley Online Library
A subset of B cells with unique phenotypic and functional features—termed Age‐associated
B cells (ABCs)—has recently been identified in both mice and humans. These cells are …

Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas

S Kong, Y Yang, Y Xu, Y Wang… - Proceedings of the …, 2016 - National Acad Sciences
Humoral immunity involves multiple checkpoints during B-cell development, maturation, and
activation. The cell death receptor CD95/Fas-mediated apoptosis plays a critical role in …

In Vitro and In Vivo Data

M Magatti, MH Abumaree, AR Silini… - Placenta: The tree …, 2016 - api.taylorfrancis.com
This chapter focuses on the immunomodulatory properties of placental mesenchymal
stromal cells (MSCs) derived from the amniotic membrane, umbilical cord, and cho rionic …

Interplay of IL-4, IL-21, and ifnγ on memory B cell fate decisions

MS Naradikian - 2016 - search.proquest.com
The ability to establish a durable pool of memory B (BMEM) cells is not only a key feature of
adaptive immunity but also critical for host survival upon secondary infection. Depending on …

Etude comparative de nouvelles approches thérapeutiques dans le lymphome à cellules du Manteau: utilisation des inhibiteurs de mTOR kinase et BTK

S Alkhaeir - 2016 - theses.hal.science
La voie PI3Kinase/AKT/mTOR, est une cible thérapeutique du temsirolimus, un inhibiteur de
mTORC1. Dans le but d'obtenir une inhibition plus importante de cette voie j'utilise dans ce …

The role of Fc gamma receptors in the activity of therapeutic monoclonal antibodies

RJ Oldham - 2016 - eprints.soton.ac.uk
Fc gamma receptors (FcγRs) are the major family of receptors responsible for interacting
with immunoglobulin G (IgG). They are known to be required for the anti-tumour activity of …

The role of lymphocyte tolerance mechanisms in constraining the production of neutralizing HIV-1 antibodies

KMS Schroeder - 2016 - search.proquest.com
HIV-1 broadly neutralizing antibodies (bnAbs) recognize conserved regions of the Envelope
trimer and are capable of neutralizing up to 98% of cross-clade HIV-1 strains in vitro …