MicroRNAs (miRNAs) are short non-coding RNAs that act as important regulators of gene
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Epigenetic abnormalities are part of the pathogenetic alterations involved in the
development of rheumatic disorders. In this context, the main musculoskeletal cell lineages …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is
characterized by synovial hyperplasia and progressive joint destruction. The activation of RA …

Recent breakthroughs in genetic explorations have extended our understanding through
discovery of genetic patterns subjected to autoimmune diseases (AID). Genetics, on the …

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level through base-pairing predominantly with a 3'-untranslated …

Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow
limitation associated with chronic inflammation. Matrix metalloproteinases (MMPs) are …

Objective Synovial fibroblasts (SFs) produce matrix‐degrading enzymes that cause joint
destruction in rheumatoid arthritis (RA). Epigenetic mechanisms play a pivotal role in …

Objectives Epigenetic modifications play an important role in the regulation of gene
transcription and cellular function. Here, we examined if pro-inflammatory factors present in …

At least 30% of patients with rheumatoid arthritis (RA) do not respond to biologic agents,
which emphasizes the need of predictive biomarkers. We aimed to identify microRNAs …