Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …

The development of next-generation sequencing as a cost-effective technology has
facilitated the analysis of bacterial population structure at a whole-genome level and at …

In Europe, each year, more than four milion patients acquire a healthcare-associated
infection (HAI) and almost 40 thousand die as a direct consequence of it. Regardless of …

Rationale: The development of molecular diagnostics that detect both the presence of
Mycobacterium tuberculosis in clinical samples and drug resistance–conferring mutations …

The population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent of
typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to …

Background Combating the spread of drug resistant tuberculosis is a global health priority.
Whole genome association studies are being applied to identify genetic determinants of …

Mycobacterium tuberculosis remains a leading cause of death worldwide, especially among
individuals infected with HIV. Whereas phylogenetic analysis has revealed M. tuberculosis …

Tuberculosis (TB) remains one of the most common infectious diseases caused by
Mycobacterium tuberculosis complex (MTBC). To panoramically analyze MTBC's genomic …

Abstract Background Approximately 10% of the Mycobacterium tuberculosis genome is
made up of two families of genes that are poorly characterized due to their high GC content …

Molecular diagnostics that rapidly and accurately predict resistance to fluoroquinolone drugs
and especially later-generation agents promise to improve treatment outcomes for patients …