The pancreatic β-cell: a bioenergetic perspective
DG Nicholls - Physiological reviews, 2016 - journals.physiology.org
The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review
applies an external bioenergetic critique to the central processes of glucose-stimulated …
applies an external bioenergetic critique to the central processes of glucose-stimulated …
The Significance of Tinospora crispa in Treatment of Diabetes Mellitus
A Thomas, EK Rajesh, DS Kumar - Phytotherapy research, 2016 - Wiley Online Library
Tinospora crispa is a medicinal plant belonging to the botanical family Menispermiaceae.
The plant is widely distributed in Southeast Asia and the northeastern region of India. A …
The plant is widely distributed in Southeast Asia and the northeastern region of India. A …
Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival
Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a
fundamental role in endocrine pancreatic function. In the present study expression of PYY …
fundamental role in endocrine pancreatic function. In the present study expression of PYY …
Effects of aqueous extract of alfalfa on hyperglycemia and dyslipidemia in alloxan-induced diabetic Wistar rats
MK Farsani, E Amraie, P Kavian… - … Medicine and Applied …, 2016 - akjournals.com
Background The aim of this study was to investigate the effects of aqueous extract of alfalfa
on blood glucose and serum lipids in alloxan-induced diabetic rats. Materials and methods …
on blood glucose and serum lipids in alloxan-induced diabetic rats. Materials and methods …
Biological activity and antidiabetic potential of C-terminal octapeptide fragments of the gut-derived hormone xenin
CM Martin, V Parthsarathy, A Hasib, MT Ng… - PLoS …, 2016 - journals.plos.org
Xenin is a peptide that is co-secreted with the incretin hormone, glucose-dependent
insulinotropic polypeptide (GIP), from intestinal K-cells in response to feeding. Studies …
insulinotropic polypeptide (GIP), from intestinal K-cells in response to feeding. Studies …
A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties
Background: Xenin-25 is a K-cell derived gut peptide with insulin-releasing activity which is
rapidly degraded following release into the circulation. We hypothesized that substitution of …
rapidly degraded following release into the circulation. We hypothesized that substitution of …
Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice
PJB Millar, V Pathak, RC Moffett, NM Pathak… - Molecular and Cellular …, 2016 - Elsevier
The purpose of the present study was to examine if a stable glucose-dependent
insulinotropic polypeptide (GIP) agonist could exert beneficial metabolic control in diabetic …
insulinotropic polypeptide (GIP) agonist could exert beneficial metabolic control in diabetic …
Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
Adzuki beans have long been cultivated as a food and folk medicine in East Asia. In this
study, we investigated the effect of black adzuki bean (BAB) extract on pancreatic cells and …
study, we investigated the effect of black adzuki bean (BAB) extract on pancreatic cells and …
Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice
FPM O'Harte, MT Ng, AM Lynch, JM Conlon… - Molecular and Cellular …, 2016 - Elsevier
The antidiabetic potential of thirteen novel dogfish glucagon derived analogues were
assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin …
assessed in vitro and in acute in vivo studies. Stable peptide analogues enhanced insulin …
Calcium binding and disulfide bonds regulate the stability of secretagogin towards thermal and urea denaturation
K Sanagavarapu, T Weiffert, N Ni Mhurchu… - PLoS …, 2016 - journals.plos.org
Secretagogin is a calcium-sensor protein with six EF-hands. It is widely expressed in
neurons and neuro-endocrine cells of a broad range of vertebrates including mammals …
neurons and neuro-endocrine cells of a broad range of vertebrates including mammals …