Graft inflammation impairs the induction of solid organ transplant tolerance and enhances
acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced …

Ischemia–reperfusion injury is a well-known pathological hallmark associated with diabetic
retinopathy, glaucoma, and other related retinopathies that ultimately can lead to visual …

Historically, there has been confusion relating to the diagnostic nomenclature for individual
cell death. Toxicologic pathologists have generally used the terms “single cell necrosis” and …

It is well established that maladaptive innate immune responses to sterile tissue injury
represent a fundamental mechanism of disease pathogenesis. In the context of cardiac …

Inflammation is a physiologic component of pregnancy and parturition. Overwhelming
intrauterine inflammatory load promotes quiescent feto‐maternal tissues into a contractile …

The ability to use mesenchymal stromal cells (MSC) directly out of cryostorage would
significantly reduce the logistics of MSC therapy by allowing on-site cryostorage of …

High mobility group box 1 (HMGB1) is a nuclear protein that can be released from activated
or dead cells. Extracellular HMGB1 can serve as a “danger signal” and novel cytokine that …

Abstract CD103+ dendritic cells (DCs) in nonlymphoid organs exhibit two main functions:
maintaining tolerance by induction of regulatory T cells and protecting against tissue …

Heart transplantation (HTx) is the ultimate treatment for end-stage heart failure. The number
of patients on waiting lists for heart transplants, however, is much higher than the number of …

Increased plasma cell‐free mitochondrial DNA (cf‐mDNA), a damage‐associated molecular
pattern (DAMP) produced by cellular injury, contributes to neutrophil activation/inflammation …