Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …

The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that
includes more than 100000 members among eukaryotes and prokaryotes. Acetylation …

Recent years have witnessed an emergence of a new class of therapeutic agents, termed
histone deacetylase 6 (HDAC6) inhibitors. HDAC6 is one isoform of a family of HDAC …

Alcohol consumption during pregnancy and its damaging consequences on the developing
infant brain are significant public health, social, and economic issues. The major distinctive …

Living eukaryotic systems evolve delicate cellular mechanisms for responding to various
environmental signals. Among them, epigenetic machinery (DNA methylation, histone …

Reversible histone acetylation and deacetylation at the N-terminus of histone tails play a
crucial role in regulation of gene activity. Hyperacetylation of histones relaxes chromatin …

A robust method was developed and optimized for enrichment and quantitative analysis of
posttranslational modifications (PTMs) in serum/plasma samples by combining …

Pancreatic ductal adenocarcinoma (PDAC) is often viewed to arise primarily by genetic
alterations. However, today we know that many aspects of the cancer phenotype require a …

Post‐translational chromatin modifications are an important regulatory mechanism in light
signalling and circadian clock function. The regulation of diurnal transcript level changes …

Addictions are public health menaces. However, despite advances in addiction research,
the cellular or molecular mechanisms that cause transition from recreational use to addiction …