Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

1372 Heparin and anticoagulation Akihiro Onishi1, Kalib St Ange1, Jonathan S. Dordick1, Robert
J. Linhardt1 1Center for Biotechn Page 1 1372 [Frontiers in Bioscience, Landmark, 21 …

Fibroblast growth factors (fgfs) are widely believed to activate their receptors by mediating
receptor dimerization. Here we show, however, that the FGF receptors form dimers in the …

Heparin is a naturally occurring, highly sulfated polysaccharide that plays a critical role in a
range of different biological processes. Therapeutically, it is mostly commonly used as an …

Heparin and heparan sulfates are closely related linear anionic polysaccharides, called
glycosaminoglycans, which exhibit a number of important biological and pharmacological …

Cell communication is central to the integration of cell function required for the development
and homeostasis of multicellular animals. Proteins are an important currency of cell …

Lung cancer is the leading cause of cancer-related death in developed countries. Recently,
molecular targeted therapies have shown promising results in the management of lung …

The fibroblast growth factors (FGFs) are a family of cell intrinsic regulatory peptides that
control a broad spectrum of cellular activities. The family includes canonic FGFs that elicit …

Fibroblast growth factors (FGFs) are a family of pleiotropic factors produced by stromal and
parenchymal tumor cells. Even though FGFs have been firstly characterized as angiogenic …