Deep brain stimulation (DBS) is highly effective for both hypo-and hyperkinetic movement
disorders of basal ganglia origin. The clinical use of DBS is, in part, empiric, based on the …

The suppression of inappropriate actions is critical for flexible behavior. Cortical-basal
ganglia networks provide key gating mechanisms for action suppression, yet the specific …

Impulsivity and compulsivity have emerged as important dimensional constructs that
challenge traditional psychiatric classification systems. Both are present in normal healthy …

Surprising events markedly affect behaviour and cognition, yet the underlying mechanism is
unclear. Surprise recruits a brain mechanism that globally suppresses motor activity …

Background Rapid action stopping leads to global motor suppression. This is shown by
studies using transcranial magnetic stimulation to measure corticospinal excitability of task …

Progressive supranuclear palsy and Parkinson's disease have distinct underlying
neuropathology, but both diseases affect cognitive function in addition to causing a …

Flexible behavior requires a control system that can inhibit actions in response to changes in
the environment. Recent studies suggest that people proactively adjust response …

The abilities to select appropriate responses and suppress unwanted actions are key
executive functions that enable flexible and goal-directed behavior. However, to date it has …

We developed a circuit model of spiking neurons that includes multiple pathways in the
basal ganglia (BG) and is endowed with feedback mechanisms at three levels: cortical …

Rationale Stress increases alcohol consumption and the risk of relapse, but little is known
about the psychological mechanisms that underlie these effects. One candidate mechanism …