Ventilator-associated pneumonia is the most common infection in intensive care unit
patients associated with high morbidity rates and elevated economic costs; Pseudomonas …

Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …

Purpose This study aims to determine if continuous infusion (CI) is associated with better
clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent …

Beta-lactam antibiotics serve as a cornerstone in the management of bacterial infections
because of their wide spectrum of activity and low toxicity. Since resistance rates among …

Antibiotics are invaluable in the management of neonatal infections. However, overuse or
misuse of antibiotics in neonates has been associated with adverse outcomes, including …

Results Sixty-eight participants had data for analysis. Regardless of infusion duration, 6 g/d
piperacillin was associated with≤ 45% target attainment, whereas 12 g/d was associated …

A better dosing strategy can improve clinical outcomes for patients. We systematically
reviewed the literatures to determine whether any clinical benefits exist for piperacillin …

目的概述哌拉西林他唑巴坦优化给药方案的研究进展, 为临床合理应用提供参考.
方法检索国内外发表的相关文献, 比较哌拉西林/他唑巴坦采用延长输注/持续输注优化给药方案 …

Sepsis and related changes lead to an array of physiological changes in critically ill patients.
As with all other interventional measures, early and appropriate antibiotic regimen is …

Al igual que otros antibióticos beta-lactámicos, piperacilina-tazobactam muestra un efecto
antibacteriano tiempo-dependiente. Dado que se requiere que las concentraciones …