Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively
aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and …

Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk
between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen …

Th17 cells accrue in the intestine in response to particular microbes. In rodents, segmented
filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously functioning …

Objectives To review the pathophysiology, co-morbidities, and therapeutic options for
psoriasis, psoriatic arthritis and rheumatoid arthritis in order to further understand the …

Background Immune-mediated inflammatory diseases (IMIDs) are a group of complex and
prevalent diseases where disease diagnostic and activity monitoring is highly challenging …

Aberrant expression of long noncoding RNAs has recently been reported in tumorigenesis
and plays a pivotal role in regulating malignant behavior of cancers. In this study, we …

Abstract Interleukin-21 (IL-21) is a member of the common γ-chain cytokines with broad
pleiotropic actions that affects different immune and nonimmune cells. IL-21 can affect …

Purpose The purpose of this study is to evaluate the pharmacokinetics, immunogenicity,
safety, and tolerability of guselkumab, a human monoclonal antibody with high affinity and …

Although genome-wide association studies have revealed important insights into the global
genetic basis of psoriasis, the findings require further investigation. At present, the known …

Genome-wide association studies (GWAS) have identified a large number of disease-
associated SNPs, but in few cases the functional variant and the gene it controls have been …