Systemic sclerosis (SSc) is a chronic autoimmune disease with a high morbidity and
mortality. Skin and organ fibrosis are key manifestations of SSc, for which no generally …

Lung fibrosis is the hallmark of the interstitial lung diseases. Alveolar epithelial cell (AEC)
injury is a key step that contributes to a profibrotic microenvironment. Fibroblasts and …

In contrast to the lab mouse, Mus musculus, several species of spiny mouse, Acomys, can
regenerate epidermis, dermis, hairs, sebaceous glands with smooth muscle erector pili …

Rationale: The potent immunomodulatory cytokine IL-6 is consistently up-regulated in
human lungs with emphysema and in mouse emphysema models; however, the …

Asiatic acid (AA) is one of the major components of Titrated extract of Centella asiatica
(TECA), which has been reported to possess antioxidant and anti-inflammatory activities …

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with few treatment options and
poor prognosis. Emodin, extracted from Chinese rhubarb, was found to be able to alleviate …

Idiopathic pulmonary fibrosis is a devastating lung disease with limited treatment options.
The signaling molecule adenosine is produced in response to injury and serves a protective …

Purpose Viruses are a common cause of exacerbations in chronic obstructive pulmonary
disease (COPD). They activate toll-like receptors (TLRs) 3, 7, and 8, leading to a pro …

The liver-X-receptors have shown anti-fibrosis ability in several animal models. Our purpose
was to investigate the effect of LXRs in bleomycin induced lung fibrosis in mice. Bleomycin …

COPD is a chronic inflammatory disease of the airways where many patients have recurrent
lower airway bacterial infection, most commonly nontypeable Haemophilus influenzae …