Adipose tissue de novo lipogenesis (DNL) positively influences insulin sensitivity, is reduced
in obesity, and predicts insulin resistance. Therefore, elucidating mechanisms controlling …

Although nicotinamide nucleotide transhydrogenase (NNT)–deficient C57BL/6J (6J) mice
are known to be highly susceptible to diet-induced metabolic disease, this notion stems …

FGF21 improves the metabolic profile of obese animals through its actions on adipocytes. To
elucidate the signaling network responsible for mediating these effects, we quantified …

Background: Since 1981, we have used the term metabolic syndrome to describe an
association of a dysregulation in lipid metabolism (high triglycerides, low high-density …

Insulin resistance is associated with deregulation of insulin signaling owing to the chronic
exposure of insulin (hyperinsulinemia) to the tissues. Phosphorylation and …

Hyperinsulinemia, which is associated with aging and metabolic disease, may lead to
defective protein homeostasis (proteostasis) due to hyperactivation of insulin-sensitive …

Previous study has shown that curcumin directly or indirectly suppresses insulin signaling in
3T3-L1 adipocytes. However, the underlying mechanism remains unclear. Here we …

Aim Carotenoids may reduce the risk of insulin resistance (IR) due to their antioxidant
properties. The aim of the present study was to investigate the relationship between dietary …

Although the insulin-mediated cell signaling pathway has been extensively examined,
changes in the cellular content of metabolites currently remain unclear. We herein examined …

This dissertation's main focus is on how yeast beta-glucans affect:(1) the glycemic control of
diabetes (fasting blood glucose, proportion of glycated hemoglobin and postprandial …