Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …

Genomic technologies have evolved rapidly contributing to the understanding of diseases.
Genome-wide association studies (GWAS) and whole-exome sequencing have aided the …

Osteoporosis, or bone loss, is a progressive, systemic skeletal disease that affects millions of
people worldwide. Osteoporosis is generally age related, and it is underdiagnosed because …

Background Genetic determinants of stroke, the leading neurological cause of death and
disability, are poorly understood and have seldom been explored in the general population …

Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …

Bone mineral density (BMD) is a quantitative traits used as a surrogate phenotype for the
diagnosis of osteoporosis, a common metabolic disorder characterized by increased fracture …

Genome-wide association and fine-mapping studies in 14 autoimmune diseases (AID) have
implicated more than 250 loci in one or more of these diseases. As more than 90% of AID …

Bone mineral density (BMD) is a measure of osteoporosis and is useful in evaluating the risk
of fracture. In a genome-wide association study of BMD among 20,100 Icelanders, with …

Osteoporosis is the most common multifactorial metabolic bone disorder worldwide with a
strong genetic component. In this review, the evidence for a genetic contribution to …

The pathogenesis of osteoporosis, a common disease with great morbidity and mortality,
comprises environmental and genetic factors. As with other complex disorders, the genetic …