The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure
upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also …

The liver is a highly metastasis-permissive organ, tumor seeding of which usually portends
mortality. Its unique and diverse architectural and cellular composition enable the liver to …

Exosomes mediate intercellular microRNA delivery between hepatic stellate cells (HSC), the
principal fibrosis‐producing cells in the liver. The purpose of this study was to identify …

Hepatic stellate cells (HSCs) are critical mediators of immunosuppression and the
pathogenesis of hepatocellular carcinoma (HCC). Our previous work indicates that HSCs …

Hepatic stellate cells (HSCs) induce immune privilege and promote hepatocellular
carcinoma (HCC) by suppressing the immune system. On the other hand, galectin-1 and …

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is one of the most common
cancers in HBV-endemic regions, with irreversible progression and poor prognosis. HBV …

We demonstrated previously that mouse hepatic stellate cells (HSCs) suppress T cells via
programmed death–ligand 1 (PD-L1), but it remains unknown whether they exert any effects …

Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes
mellitus with persistent risk of glycaemic alterations and life‐threatening complications …

Both experimental and clinical studies have shown that the liver possesses unique
tolerogenic properties. Liver allografts can be spontaneously accepted across complete …

Abstract Background Intact Toll-like receptor 4 (TLR4) has been identified in hepatic stellate
cells (HSCs), the primary fibrogenic cell type in liver. Here, we investigated the impact of …