Understanding cachexia as a cancer metabolism syndrome
PE Porporato - Oncogenesis, 2016 - nature.com
Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …
STAT3 in the systemic inflammation of cancer cachexia
Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia
M Lemper, S De Groef, G Stangé, L Baeyens… - Diabetologia, 2016 - Springer
Aims/hypothesis When the beta cell mass or function declines beyond a critical point,
hyperglycaemia arises. Little is known about the potential pathways involved in beta cell …
hyperglycaemia arises. Little is known about the potential pathways involved in beta cell …