Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology
CC Raiss, TS Braun, IBM Konings, H Grabmayr… - Scientific reports, 2016 - nature.com
The formation of α-synuclein (α-S) amyloid aggregates, called Lewy bodies (LBs), is a
hallmark of Parkinson's disease (PD). The function of LBs in the disease process is however …
hallmark of Parkinson's disease (PD). The function of LBs in the disease process is however …
The inhibition of IGF‐1 signaling promotes proteostasis by enhancing protein aggregation and deposition
L Moll, T Ben‐Gedalya, H Reuveni… - The FASEB …, 2016 - Wiley Online Library
The discovery that the alteration of aging by reducing the activity of the insulin/IGF‐1
signaling (IIS) cascade protects nematodes and mice from neurodegeneration‐linked, toxic …
signaling (IIS) cascade protects nematodes and mice from neurodegeneration‐linked, toxic …
PrP-containing aggresomes are cytosolic components of an ER quality control mechanism
T Dubnikov, T Ben-Gedalya, R Reiner… - Journal of cell …, 2016 - journals.biologists.com
Limited detoxification capacity often directs aggregation-prone, potentially hazardous,
misfolded proteins to be deposited in designated cytosolic compartments known as …
misfolded proteins to be deposited in designated cytosolic compartments known as …
[图书][B] Characterization of ubiquitin-proteasome dynamics in Caenorhabditis elegans muscle cells during protein-folding stress
GA Skibinski - 2016 - search.proquest.com
In order to adapt to changing conditions and life stages, cells must remodel the composition
of the proteome by specifically removing obsolete or damaged proteins. Failure to remove …
of the proteome by specifically removing obsolete or damaged proteins. Failure to remove …